Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6-secreting tumor
| Autor: | S. Metzger, Orit Pappo, V. Barash, T. Chajek-Shaul, T. Hassin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology Ratón Endocrinology Diabetes and Metabolism Fibrosarcoma Adipose tissue Gene Expression Fatty Acids Nonesterified Glucosephosphate Dehydrogenase Transfection chemistry.chemical_compound Mice Physiology (medical) Internal medicine medicine Tumor Cells Cultured Glucose-6-phosphate dehydrogenase Animals Secretion Interleukin 6 Triglycerides biology Triglyceride Cholesterol Interleukin-6 Cholesterol HDL Fatty Acids Metabolism Lipids Mice Inbred C57BL Lipoprotein Lipase Endocrinology chemistry Adipose Tissue Liver biology.protein Body Composition Hepatocytes Female Cell Division Neoplasm Transplantation |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 281(5) |
| ISSN: | 0193-1849 |
| Popis: | Chronic secretion of interleukin-6 (IL-6) in mice causes metabolic alteration in the liver, leading to increased synthesis of hepatic cholesterol and fatty acids (FA). Mice were injected with allogeneic tumor cells transduced with the murine IL-6 gene. During the 3 wk after tumor inoculation, elevated serum IL-6 levels were associated with increased spleen and liver weight. Histological examination of sections from the liver showed increased hepatocyte proliferation, resulting in liver enlargement. Body composition analysis revealed that IL-6 caused a significant loss in fat tissue without affecting lean body mass and water content. Hepatic de novo synthesis of FA and cholesterol, as measured by3H2O incorporation, was three to five times as high in mice secreting IL-6 (IL-6 mice) as in pair-fed mice bearing nonsecreting tumors. This increase in FA and cholesterol synthesis is sufficient to maintain hepatic triglyceride secretion at levels comparable with those of pair-fed mice bearing nonsecreting tumors and, presumably, is the main source of cholesterol and FA-phospholipids necessary for hepatocyte proliferation. |
| Databáze: | OpenAIRE |
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