Glucose modulates Drosophila longevity and immunity independent of the microbiota
| Autor: | Anthony Galenza, Shelagh D. Campbell, Edan Foley, Bart Hazes, Jaclyn Hutchinson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
QH301-705.5 Protein to carbohydrate Science media_common.quotation_subject Physiology Carbohydrate metabolism General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immunity Diabetes mellitus medicine Microbiome Biology (General) Drosophila Organism Nutrition 030304 developmental biology media_common 2. Zero hunger 0303 health sciences biology Ecology Longevity biology.organism_classification medicine.disease 3. Good health Ageing Malnutrition 030104 developmental biology Drosophila melanogaster General Agricultural and Biological Sciences 030217 neurology & neurosurgery Research Article |
| Zdroj: | Biology Open Biology Open, Vol 5, Iss 2, Pp 165-173 (2016) |
| DOI: | 10.1101/027326 |
| Popis: | The acquisition of nutrients is essential for maintenance of metabolic processes in all organisms. Nutritional imbalance contributes to myriad metabolic disorders that include malnutrition, diabetes and even cancer. Recently, the importance of macronutrient ratio of food has emerged as a critical factor to determine health outcomes. Here we show that individual modifications to a completely defined diet markedly impact multiple aspects of organism wellbeing in Drosophila melanogaster. Through a longitudinal survey of several diets we demonstrate that increased levels of dietary glucose significantly improve longevity and immunity in adult Drosophila. Our metagenomic studies show that relative macronutrient levels not only influence the host, but also have a profound impact on microbiota composition. However, we found that elevated dietary glucose extended the lifespan of adult flies even when raised in a germ-free environment. Furthermore, when challenged with a chronic enteric infection, flies fed a diet with added glucose had increased survival times even in the absence of an intact microbiota. Thus, in contrast to known links between the microbiota and animal health, our findings uncover a novel microbiota-independent response to diet that impacts host wellbeing. As dietary responses are highly conserved in animals, we believe our results offer a general understanding of the association between glucose metabolism and animal health. Summary: Dietary glucose improves both longevity and immunity in adult Drosophila through a mechanism independent of the intestinal microbiota. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|