Development of MPC-DPA polymeric nanoparticle systems for inhalation drug delivery applications
| Autor: | Jonathan P. Salvage, Abdul Khaliq El-Zhry El-Yafi, Steve Meikle, Andrew L. Lewis, Guy Standen |
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| Rok vydání: | 2017 |
| Předmět: |
Microscopy
Electron Scanning Transmission Curcumin Materials science Phosphorylcholine Dispersity Pharmaceutical Science Nanoparticle Nanotechnology 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Chitosan chemistry.chemical_compound Polymethacrylic Acids Coating Administration Inhalation Drug Carriers 021001 nanoscience & nanotechnology 0104 chemical sciences Solubility chemistry Drug delivery Solvents engineering Nanoparticles Nanomedicine Nanocarriers 0210 nano-technology Drug carrier |
| Zdroj: | European Journal of Pharmaceutical Sciences. 106:362-380 |
| ISSN: | 0928-0987 |
| DOI: | 10.1016/j.ejps.2017.06.023 |
| Popis: | Inhalation of nanoparticles for pulmonary drug delivery offers the potential to harness nanomedicine formulations of emerging therapeutics, such as curcumin, for treatment of lung cancer. Biocompatible nanoparticles composed of poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) have been shown to be suitable nanocarriers for drugs, whilst N-trimethyl chitosan chloride (TMC) coating of nanoparticles has been reported to further enhance their cellular delivery efficacy; the combination of the two has not been previously investigated. Development of effective systems requires the predictable, controllable, and reproducible ability to prepare nanosystems possessing particle sizes, and drug loading capacities, appropriate for successful airway travel, lung tissue penetration, and tumor suppression. Although a number of MPC-DPA based nanosystems have been described, a complete understanding of parameters controlling nanoparticle formation, size, and morphology has not been reported; in particular the effects of differing solvents phases remains unclear. In this current study a matrix of 31 solvent combinations were examined to provide novel data pertaining to the formation of MPC-DPA nanoparticles, and in doing so afforded the selection of systems with particle sizes appropriate for pulmonary delivery applications to be loaded with curcumin, and coated with TMC. This paper presents the first report of novel data detailing the successful preparation, characterisation, and optimisation of MPC-DPA nanoparticles of circa 150-180nm diameter, with low polydispersity, and a curcumin loading range of circa 2.5-115μM, tunable by preparation parameters, with and without TMC coating, and thus considered suitable candidates for inhalation drug delivery applications. |
| Databáze: | OpenAIRE |
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