Ibero-American Expert Consensus on Squamous Cell Carcinoma of the Head and Neck Treatment in Patients Unable to Receive Cisplatin: Recommendations for Clinical Practice
| Autor: | Jon Cacicedo, Ricard Mesia, José Luis Aguilar-Ponce, Thiago Bueno Oliveira, Tannia Soria, Neck Cancer, Agustin Falco, Antonio Rueda-Domínguez, Miren Taberna, Taysser Sowley, Marcos David Pereira, Héctor Galindo, Aylen Vanessa Ospina, Miguel Ángel Ticona, Lara Iglesias |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment cisplatin Review frailty comorbidities Nephrotoxicity Ototoxicity Quality of life Weight loss Internal medicine Medicine Contraindication Cisplatin Performance status business.industry toxicity medicine.disease Radiation therapy age medicine.symptom business contraindication medicine.drug |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s322411 |
| Popis: | Cisplatin is the standard of treatment for squamous cell carcinoma of the head and neck (SCCHN) that has demonstrated efficacy, either in locally advanced disease when combined with radiotherapy at high doses, or in metastatic/recurrent disease when combined with other agents. However, the usual toxicities related to cisplatin, such as neurotoxicity, nephrotoxicity, ototoxicity, and hematologic toxicities, especially when high doses have been administered, have important implications in the patients’ quality of life. The decision to administer cisplatin depends on several patient factors, such as age, performance status, weight loss, comorbidities, previous toxicities, chronic viral infection, or even the current SARS-CoV-2 pandemic. In order to establish recommendations for the management of patients with SCCHN, a group of experts in medical and radiation oncology from Spain and Latin-American discussed how to identify patients who are not candidates for cisplatin to offer them the most suitable therapeutic alternative. |
| Databáze: | OpenAIRE |
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