Combination Drug Therapy for Cryptosporidiosis in AIDS
| Autor: | Luis Manuel Valdez, A. Clinton White, Cynthia L. Chappell, Nathaniel H. Smith, Stanley G. Cron |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy Paromomycin Opportunistic infection Cryptosporidiosis Azithromycin Pharmacotherapy Internal medicine parasitic diseases medicine Animals Humans Immunology and Allergy AIDS-Related Opportunistic Infections biology business.industry medicine.disease biology.organism_classification Antiparasitic agent Anti-Bacterial Agents Diarrhea Treatment Outcome Infectious Diseases Cryptosporidium parvum Immunology Coccidiostats Drug Therapy Combination Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 178:900-903 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/515352 |
| Popis: | Aside from effective antiretroviral therapy, there is no consistently effective antiparasitic therapy for cryptosporidiosis in AIDS. The purpose of this study was to assess safety, efficacy, and durability of combination therapy with paromomycin and azithromycin for chronic cryptosporidiosis. Patients with AIDS, chronic cryptosporidiosis, and100 CD4 cells/microL were treated with open-label paromomycin (1.0 g twice a day) plus azithromycin (600 mg once a day) for 4 weeks, followed by paromomycin alone for 8 weeks. In 11 patients, median stool frequency decreased from 6.5/day (baseline) to 4.9/day (week 4) and 3.0/day (week 12). Median reductions in 24-h oocyst excretion were 84%, 95%, and99% at 2, 4, and 12 weeks, respectively. None of the responses were attributable to antiretrovirals. Of 5 survivors at 12-30 months of follow-up, 3 remain asymptomatic off medications, and 2 have chronic, mild diarrhea. Treatment of cryptosporidiosis with azithromycin and paromomycin was associated with significant reduction in oocyst excretion and some clinical improvement. |
| Databáze: | OpenAIRE |
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