Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration
| Autor: | Yusuke Kanda, Saori Suzuki Ikeda, Kunishige Onuma, Mitsuhiko Osaki, Masanobu Kobayashi, Futoshi Okada, Masataka Shikanai, Takuya Nonomura, Ryuta Sakaki, Hiroshi Kobayashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Carcinogenesis
Aspergillus oryzae Chemokine CXCL2 CCL3 Inflammation lcsh:TX341-641 medicine.disease_cause Article Mice inflammation-related carcinogenesis Neoplasms medicine fermented brown rice and rice bran with Aspergillus oryzae (FBRA) inflammation Animals Chemokine CCL3 Nutrition and Dietetics biology Tumor Necrosis Factor-alpha Oryza biology.organism_classification medicine.disease Diet Mice Inbred C57BL Oxidative Stress Biochemistry Fermentation Cancer research Brown rice Tumor necrosis factor alpha Female medicine.symptom Infiltration (medical) lcsh:Nutrition. Foods and food supply Oxidative stress Food Science DNA Damage |
| Zdroj: | Nutrients Volume 7 Issue 12 Pages 10237-10250 Nutrients, Vol 7, Iss 12, Pp 10237-10250 (2015) Nutrients; Volume 7; Issue 12; Pages: 10237-10250 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu7125531 |
| Popis: | We have established an inflammation-related carcinogenesis model in mouse, in which regressive QR-32 cells subcutaneously co-implanted with a foreign body—gelatin sponge—convert themselves into lethal tumors due to massive infiltration of inflammatory cells into the sponge. Animals were fed with a diet containing 5% or 10% fermented brown rice and rice bran with Aspergillus oryzae (FBRA). In 5% and 10% FBRA diet groups, tumor incidences were lower (35% and 20%, respectively) than in the non-treated group (70%). We found that FBRA reduced the number of inflammatory cells infiltrating into the sponge. FBRA administration did not cause myelosuppression, which indicated that the anti-inflammatory effects of FBRA took place at the inflammatory lesion. FBRA did not have antitumor effects on the implanted QRsP-11 tumor cells, which is a tumorigenic cell line established from a tumor arisen after co-implantation of QR-32 cells with sponge. FBRA did not reduce formation of 8-hydroxy-2′-deoxyguanine adducts, a marker of oxidative DNA damage in the inflammatory lesion however, it reduced expression of inflammation-related genes such as TNF-α, Mac-1, CCL3 and CXCL2. These results suggest that FBRA will be an effective chemopreventive agent against inflammation-related carcinogenesis that acts by inhibiting inflammatory cell infiltration into inflammatory lesions. |
| Databáze: | OpenAIRE |
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