A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: The QUEST Phantom Study

Autor: Renaud Lhommel, P. F. Staanum, Alexander S. Pasciak, A. Sheikh, K. P. Willowson, A. Hallam, M. J. Tapner, Maurizio Conti, M. Reindl, S. Civollani, M. Ferrari, R. Muzaffar, Josep M. Martí-Climent, E. Fourkal, Martin A. Lodge, Francois Benard, Stephen C. Moore, H.-J. Kaiser, S. Holm, Matthias Miederer, Holger Amthauer, M. Cervo, Macarena Rodríguez-Fraile, Jan Boucek, S. Heard, Bieke Lambert, Patricia G. Judy, R. A. Pooley, Levent Kabasakal, N. Song, F. Molina-Duran, M. Luster, S. C. Ng, Felix M. Mottaghy, Gerhard Glatting, Austin C. Bourgeois, Alfredo Lopez, K. S. Nijran, O. S. Großer, Graeme O'Keefe, Kathy Willowson, B. McLamb, A. M. Fletcher, T. Eugene, Michael Lassmann, O. Geatti, M. D’Andrea, Jann Mortensen, D. L. Bailey, S. Schlögl, G. Iaccarino, M. D’Arienzo, R. U. Mulder, Yves D'Asseler, Thomas Carlier, Roslyn J. Francis, V. H. Lee, Javier Arbizu, A. J. Craig, Claire A. Hooker, James R. Stone, J. Ouyang, D. J. Towey, Leonard M. Freeman, Dale L. Bailey, P. J. Julyan, N. Yu, A. Goedicke, H. Tanyildizi, M. Cremonesi, J. M. McKinney, W. Siman, C. M.R. Habito, K. A. Büsing, Daniel R. McGowan, Cinzia Pettinato, R. de Nijs, S. P. Jeans, Patrick Flamen, Ole Lajord Munk, F Di Martino, Darren G. Morgan, Mohan Doss, Hojjat Ahmadzadehfar, M. W. Law, F. Leek, Martha Hoffmann, S. O. Schönberg, Ali Asgar Attarwala, G. D. Flux, F. Bonutti, L. Filippi, S. M. Srinivas, Hans-Georg Buchholz, Ivo Rausch, F. Botta, Heying Duan, S. C. Kappadath, Bruno Vanderlinden, Michael Tapner, A. Celler, G. Weir, Medhat Osman, O. Bagni, Yong C. Bradley, L. Strigari
Přispěvatelé: Beeldvorming, MUMC+: DA BV Medische staf (6), RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging, 42(8), 1202-1222. Springer, Cham
European journal of nuclear medicine and molecular imaging 42(8), 1202-1222 (2015). doi:10.1007/s00259-015-3059-9
European journal of nuclear medicine and molecular imaging, 42 (8
ISSN: 1619-7070
Popis: Purpose: To investigate and compare the quantitative accuracy of 90Y imaging across different generation PET/CT scanners, for the purpose of dosimetry after radioembolization with resin microspheres. Methods: A strict experimental and imaging protocol was followed by 47 international sites using the NEMA 2007/IEC 2008 PET body phantom with an 8-to-1 sphere-to-background ratio of 90Y solution. The phantom was imaged over a 7-day period (activity ranging from 0.5 to 3.0 GBq) and all reconstructed data were analysed at a core laboratory for consistent processing. Quantitative accuracy was assessed through measures of total phantom activity, activity concentration in background and hot spheres, misplaced counts in a nonradioactive insert, and background variability. Results: Of the 69 scanners assessed, 37 had both time-of-flight (ToF) and resolution recovery (RR) capability. These current generation scanners from GE, Philips and Siemens could reconstruct background concentration measures to within 10 % of true values over the evaluated range, with greater deviations on the Philips systems at low count rates, and demonstrated typical partial volume effects on hot sphere recovery, which dominated spheres of diameter 20 mm in diameter, activity concentrations were consistently underestimated by about 20 %. Non-ToF scanners from GE Healthcare and Siemens were capable of producing accurate measures, but with inferior quantitative recovery compared with ToF systems. Conclusion: Current generation ToF scanners can consistently reconstruct 90Y activity concentrations, but they underestimate activity concentrations in small structures (≤37 mm diameter) within a warm background due to partial volume effects and constraints of the reconstruction algorithm. At the highest count rates investigated, measures of background concentration (about 300 kBq/ml) could be estimated on average to within 1 %, 5 % and 2 % for GE Healthcare (all-pass filter, RR + ToF), Philips (4i8s ToF) and Siemens (2i21s all-pass filter, RR + ToF) ToF systems, respectively. Over the range of activities investigated, comparable performance between GE Healthcare and Siemens ToF systems suggests suitability for quantitative analysis in a scenario analogous to that of postradioembolization imaging for treatment of liver cancer.
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SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
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