The Notch and Sonic hedgehog signalling pathways in immunity
| Autor: | Robert A. Benson, Jonathan R. Lamb, Jacqueline A. Lowrey, Sarah E. M. Howie |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
animal structures Cellular differentiation Immunology Biology Cell fate determination Immune system Antigen Immunity Neoplasms Animals Humans Hedgehog Proteins Sonic hedgehog Receptor Molecular Biology Receptors Notch Membrane Proteins Cell Differentiation Pneumonia Cell biology Immune System embryonic structures Trans-Activators biology.protein Signal transduction Signal Transduction |
| Zdroj: | Molecular Immunology. 41:715-725 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2004.04.017 |
| Popis: | There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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