In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent
| Autor: | Novriana Dewi, Yoshinori Sakurai, Takayuki Nakagawa, Nobuhiro Nishiyama, Hiroki Tanaka, Kazunori Kataoka, Takehisa Matsukawa, Hiroyuki Takahashi, Horacio Cabral, Koji Ono, Minoru Suzuki, Yasuyuki Morishita, Peng Mi, Hironobu Yanagie, Yuriko Sakurai, Masashi Yanagawa, Kazuhito Yokoyama, Atsuko Shinohara |
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| Rok vydání: | 2015 |
| Předmět: |
Calcium Phosphates
Gadolinium DTPA Cancer Research MRI contrast agent Gadolinium Contrast Media chemistry.chemical_element 02 engineering and technology Calcium Injections Mice 03 medical and health sciences 0302 clinical medicine Japan In vivo Neutron flux Animals Humans Tissue Distribution Research reactor Irradiation Mice Inbred BALB C business.industry Radiochemistry Radiotherapy Dosage Neoplasms Experimental Neutron Capture Therapy General Medicine 021001 nanoscience & nanotechnology Magnetic Resonance Imaging Neutron capture Treatment Outcome Oncology chemistry 030220 oncology & carcinogenesis Colonic Neoplasms Feasibility Studies Nanoparticles Female 0210 nano-technology Nuclear medicine business |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 142:767-775 |
| ISSN: | 1432-1335 0171-5216 |
| Popis: | A more immediate impact for therapeutic approaches of current clinical research efforts is of major interest, which might be obtained by developing a noninvasive radiation dose-escalation strategy, and neutron capture therapy represents one such novel approach. Furthermore, some recent researches on neutron capture therapy have focused on using gadolinium as an alternative or complementary for currently used boron, taking into account several advantages that gadolinium offers. Therefore, in this study, we carried out feasibility evaluation for both single and multiple injections of gadolinium-based MRI contrast agent incorporated in calcium phosphate nanoparticles as neutron capture therapy agent.In vivo evaluation was performed on colon carcinoma Col-26 tumor-bearing mice irradiated at nuclear reactor facility of Kyoto University Research Reactor Institute with average neutron fluence of 1.8 × 10(12) n/cm(2). Antitumor effectivity was evaluated based on tumor growth suppression assessed until 27 days after neutron irradiation, followed by histopathological analysis on tumor slice.The experimental results showed that the tumor growth of irradiated mice injected beforehand with Gd-DTPA-incorporating calcium phosphate-based nanoparticles was suppressed up to four times higher compared to the non-treated group, supported by the results of histopathological analysis.The results of antitumor effectivity observed on tumor-bearing mice after neutron irradiation indicated possible effectivity of gadolinium-based neutron capture therapy treatment. |
| Databáze: | OpenAIRE |
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