HYPERTENSION WITH ALDOSTERONE EXCESS AND LOW PLASMA-RENIN: PREOPERATIVE DISTINCTION BETWEEN PATIENTS WITH AND WITHOUT ADRENOCORTICAL TUMOUR
| Autor: | A. F. Lever, T. Symington, J. I. S. Robertson, I.G. O'Muircheartaigh, A.M. Neville, J. J. Brown, A.W. Kay, J.B. Ferriss, R. Fraser |
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| Rok vydání: | 1970 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Adolescent Statistics as Topic Adrenal Gland Diseases Adrenal Gland Neoplasms Urology Blood Pressure Hypokalemia Spironolactone Plasma renin activity Adrenocortical adenoma Diagnosis Differential chemistry.chemical_compound Sex Factors Internal medicine Adrenal Glands Hyperaldosteronism Renin Renin–angiotensin system medicine Humans Aldosterone Aged Retrospective Studies Hyperplasia Computers business.industry Sodium Age Factors General Medicine Carbon Dioxide Middle Aged medicine.disease Endocrinology medicine.anatomical_structure chemistry Zona glomerulosa Hypertension Potassium Female business |
| Zdroj: | The Lancet. 296:995-1000 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(70)92811-4 |
| Popis: | A retrospective analysis of thirty-four patients with hypertension, hyperaldosteronism, and low plasma-renin is described. A single adrenocortical adenoma was found in twenty. No tumour was seen in eleven, and the adrenal glands of nine of these showed hyperplasia of the zona glomerulosa. A definite pathological diagnosis was not possible in three patients. Mean plasma concentrations of aldosterone, sodium, and total carbon dioxide were higher, while mean plasma concentrations of renin and potassium were lower in the tumour group, when compared with non-tumour patients. These differences were seen both in patients taking a controlled constant intake of sodium and potassium and in patients taking a normal unrestricted diet. Considerable overlap in each of the variables was found among individual patients, and straightforward analysis of the preoperative biochemical data did not permit a confident prediction of the adrenal lesion. However, a multidimensional computer-assisted analysis enabled complete separation of tumour and non-tumour groups and it is suggested that this technique may be of value in making the preoperative distinction in future cases. |
| Databáze: | OpenAIRE |
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