Epigenetic gene-expression links heart failure to memory impairment
| Autor: | Julia Cha, Tea Berulava, Christian Schiffmann, Andre Fischer, Elerdashvili Vakhtang, Dawid Lbik, Rezaul Islam, Raoul Maximilian Hofmann, Anke Zieseniss, Marti Jimenez Mausbach, M. Sadman Sakib, Karl Toischer, Farahnaz Sananbenesi, D. M. Katschinski |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
business.industry ved/biology ved/biology.organism_classification_rank.species Cognition Hippocampal formation Impaired memory medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine Heart failure Memory impairment Medicine Epigenetics business Model organism Pathological Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/2020.01.22.915637 |
| Popis: | In current clinical practice care of diseased patients is often restricted to separated disciplines. However, such an organ-centered approach is not always suitable. For example, cognitive dysfunction is a severe burden in heart failure patients. Moreover, these patients have an increased risk for age-associated dementias. The underlying molecular mechanisms are presently unknown and thus corresponding therapeutic strategies to improve cognition in heart failure patients are missing. Using mice as model organisms we show that heart failure leads to specific changes in hippocampal gene-expression, a brain region intimately linked to cognition. These changes reflect increased cellular stress pathways which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Consequently, mice suffering from heart failure exhibit impaired memory function. These pathological changes are ameliorated via the administration of a drug that promotes neuronal euchromatin formation. Our study provides first insight to the molecular processes by which heart failure contributes to neuronal dysfunction and point to novel therapeutic avenues to treat cognitive defects in heart failure patients. |
| Databáze: | OpenAIRE |
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