Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats
| Autor: | Mariangela Martini, Udita Datta, Wen Lin Sun, Meiyun Fan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Sucrose Punishment (psychology) media_common.quotation_subject Reward value Physiology Estrous Cycle Self Administration Article 03 medical and health sciences Cocaine-Related Disorders 0302 clinical medicine Cocaine Punishment Reward medicine Animals Rats Wistar media_common Pharmacology Estrous cycle Potential impact Dose-Response Relationship Drug business.industry Addiction 030227 psychiatry Rats Behavior Addictive Compulsive behavior Compulsive Behavior Female medicine.symptom Self-administration business Reinforcement Psychology 030217 neurology & neurosurgery Cocaine seeking |
| Zdroj: | Psychopharmacology. 235(8) |
| ISSN: | 1432-2072 |
| Popis: | RATIONALE: Compulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder. OBJECTIVES: This study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors. METHODS: Adult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule and then the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle. RESULTS: The rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors. CONCLUSION: Preexisting differences in compulsive sucrose-seeking behavior does not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats. |
| Databáze: | OpenAIRE |
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