Clinical and immunological characteristics in 552 systemic lupus erythematosus patients in a southern province of China
| Autor: | Zhizhong Ye, Wen-gen Li, Ke Zhang, Zhi-hua Yin |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Adolescent Anti-nuclear antibody Anemia Population Arthritis Young Adult 03 medical and health sciences Pericarditis Lupus Erythematosus Discoid 0302 clinical medicine Rheumatology Cause of Death Prevalence medicine Humans Lupus Erythematosus Systemic Photosensitivity Disorders Child Mouth ulcers education Oral Ulcer Aged Autoantibodies Retrospective Studies 030203 arthritis & rheumatology education.field_of_study Systemic lupus erythematosus business.industry Middle Aged medicine.disease Dermatology 030104 developmental biology Immunoglobulin M Immunoglobulin G Immunology Disease Progression Kidney Failure Chronic Female medicine.symptom business Malar rash Biomarkers Facial Dermatoses |
| Zdroj: | International Journal of Rheumatic Diseases. 20:68-75 |
| ISSN: | 1756-1841 |
| DOI: | 10.1111/1756-185x.12480 |
| Popis: | Aim The purpose of this study was to gain a better understanding of systemic lupus erythematosus (SLE) in Hakka populations. Methods We studied the demographic, clinical and laboratory characteristics in a cohort of 552 SLE patients diagnosed at the Rheumatology Department in MeiZhou People's Hospital from January 2008 to December 2012. There were 495 women and 57 men (8.7 : 1) with a mean age of 35.3 years (range 12–78 years). The mean age at disease onset and the mean disease duration were 31.8 ± 14.4 years and 3.3 ± 2.8 years, respectively. Results The most common clinical manifestations were arthritis (61.6%), followed by malar rash (52.7%), photosensitivity (22.8%), mouth ulcers (17.0%) and discoid lupus (14.7%). The prevalence was 46.7% for nephritis (by biopsy), 18.3% for pleuritis, 15.6% for pericarditis and 4.9% for neuropsychiatric manifestations. The most common hematological manifestations were anemia (63.8%), followed by leucopenia (29.0%) and thrombocytopenia (14.9%). Antinuclear antibodies were detected in 99.8% of patients, followed by anti-double-stranded DNA (81.3%), anti-SSA (Sjogren's syndrome antigen A)/Ro (58.7%), anti-ribonucleoprotein (36.8%), anti-Sm (35.7%), and anti-SSB/La (15.0%). Anti-cardiolipin immunoglobulin G (IgG) and IgM were detected in 18.3% and 14.1% of patients, respectively. Active disease and infections were the two major causes of death. Conclusion The clinical and immunological characteristics of the SLE patients in our study place our population in the middle of the spectrum between other Asian and Caucasian populations. |
| Databáze: | OpenAIRE |
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