Novel N-transfer reagent for converting α-amino acid derivatives to α-diazo compounds
| Autor: | Tzu Chia Huang, Guan Han Lu, Ho Hsuan Chou, Ting Wei Cho, Shin Cherng Yang, Hsiao Chin Hsueh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Metals and Alloys Diazonium Compounds Dipeptides General Chemistry Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Amino acid Transformation (genetics) chemistry.chemical_compound chemistry Reagent Materials Chemistry Ceramics and Composites Molecule Indicators and Reagents Salts Diazo Amino Acids Azo Compounds |
| Zdroj: | Chemical Communications. 57:4839-4842 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d1cc01285a |
| Popis: | A novel universal N-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides from N-terminal dipeptides (32 examples, up to 91%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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