Real-world Evaluation of glycemic control and hypoglycemic Events among type 2 Diabetes mellitus study (REEDS): a multicentre, cross-sectional study in Thailand
| Autor: | Yupin Benjasuratwong, Bancha Satirapoj, Thongchai Pratipanawatr, Wannee Nitiyanant, Sompongse Suwanwalaikorn, Boonsong Ongphiphadhanakul |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Research design
Pediatrics medicine.medical_specialty HbA1c endocrine system diseases Cross-sectional study sulfonylurea Type 2 diabetes Glycemic Control Hypoglycemia Weight Gain medicine Humans Hypoglycemic Agents Glycemic Original Research Retrospective Studies business.industry Type 2 Diabetes Mellitus nutritional and metabolic diseases General Medicine medicine.disease Thailand Metformin Diabetes and Endocrinology Cross-Sectional Studies Sulfonylurea Compounds Treatment Outcome Diabetes Mellitus Type 2 Medicine Patient Compliance Drug Therapy Combination type 2 diabetes medicine.symptom business Weight gain medicine.drug |
| Zdroj: | BMJ Open BMJ Open, Vol 10, Iss 2 (2020) |
| ISSN: | 2044-6055 |
| Popis: | ObjectivePatients with type 2 diabetes mellitus (T2DM) often experience hypoglycaemia and weight gain due to treatment side effects. Sulfonylureas (SU) and the combination of SU and metformin (SU+MET) were the most common monotherapy and combination therapies used in Thailand tertiary care hospitals. This study aimed to assess the glycaemic goal attainment rates, hypoglycaemic episodes, weight gain and treatment compliance among patients with T2DM receiving SU or SU+MET.Research design and methodsA multicentre cross-sectional survey and retrospective review was conducted in five tertiary care hospitals, Thailand. Patients with T2DM aged ≥30 years were included consecutively during a 12-month period. Glycaemic control, experiences of hypoglycaemia, weight gain and compliance were evaluated. Glycaemic goal attainment was defined by HbA1clevel less than 7%.ResultsOut of the 659 patients (mean age (±SD)), 65.5 (10.0) years and median duration of T2DM (IQR), 10 (5–15) years), 313 (47.5%) achieved the glycaemic goal. HbA1clevels in the patients with goal attainment was significantly lower compared with those without (6.3%±0.5% vs 8.1%±1.2%, pConclusionsAmong patients with T2DM receiving SU or SU+MET, only about half of the patients achieved glycaemic goal and compliance with the treatment. Hypoglycaemia and weight gain posed a significant burden with risk of weight gain higher in the SU group. |
| Databáze: | OpenAIRE |
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