Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex
| Autor: | Seung-Hwan Kwon, Seok-Yong Lee, Yong-Hyun Ko, Choon-Gon Jang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Isoorientin Scopolamine Cholinergic Agents Hippocampus CREB Antioxidants Superoxide dismutase Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Memory Neurotrophic factors Internal medicine Drug Discovery medicine Animals Cognitive Dysfunction Cyclic AMP Response Element-Binding Protein Luteolin CAMP response element binding Brain-derived neurotrophic factor Molecular Structure biology Brain-Derived Neurotrophic Factor Organic Chemistry Acetylcholinesterase Frontal Lobe 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein Molecular Medicine Signal Transduction |
| Zdroj: | Archives of Pharmacal Research. 42:722-731 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-019-01172-7 |
| Popis: | Isoorientin (ISO) is considered one of the most important flavonoids with various pharmacological effects such as antioxidant, anti-inflammatory, and anti-cancer activities. Despite these beneficial activities, the effects of ISO on learning and memory have not been investigated so far. The current study evaluated the memory-enhancing effects of ISO in a scopolamine-treated mouse model by using the Y-maze and passive avoidance tests. The results showed that ISO (5 and 10 mg/kg, p.o.) treatment significantly improved the cognitive impairments caused by scopolamine. Additionally, ISO significantly decreased scopolamine-induced acetylcholinesterase and thiobarbituric acid reactive substance activities in both the hippocampus and frontal cortex of mice. In addition, ISO significantly increased the levels of total superoxide dismutase induced by scopolamine in the hippocampus and frontal cortex. Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice. Thus, our results provide initial evidence that ISO ameliorates scopolamine-induced memory and cognitive impairments partly by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling pathway, thereby exhibiting memory-enhancing activities. |
| Databáze: | OpenAIRE |
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