Cancer biology and molecular genetics of A3 adenosine receptor
| Autor: | Chiara Mazziotta, Fernanda Martini, John Charles Rotondo, Giulia Campione, Carmen Lanzillotti, Mauro Tognon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Review Article Biology Cell membrane Mice Neoplasms Molecular genetics Genetics medicine Animals Humans Receptor Molecular Biology Cancer Cl-IB-MECA Cell growth Receptor Adenosine A3 A3 receptor Ambientale Diagnostic markers adenosine medicine.disease Adenosine Pathophysiology Disease Models Animal medicine.anatomical_structure Apoptosis Cancer research Signal Transduction medicine.drug |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A3AR has a dual nature in different pathophysiological conditions, as it is expressed according to tissue type and stimulated by an adenosine dose-dependent manner. A3AR activation leads to tumor growth, cell proliferation and survival in some cases, while triggering cytostatic and apoptotic pathways in others. This review aims to describe the most relevant aspects of A3AR activation and its ligands whereas it summarizes A3AR activities in cancer. Progress in the field of A3AR modulators, with a potential therapeutic role in cancer treatment are reported, as well. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink