Acetic Acid Bacterial Lipids Improve Cognitive Function in Dementia Model Rats
| Autor: | Takayuki Kaga, Hiroyuki Fukami, Yasukazu Tanaka, Hideki Tachimoto, Mikiya Kishi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Neurite Water maze Biology PC12 Cells Lesion Cognition Oral administration Internal medicine otorhinolaryngologic diseases medicine Acetobacter Animals Dementia Rats Wistar Maze Learning Acetic acid bacteria Acetic Acid Basal forebrain General Chemistry medicine.disease biology.organism_classification Lipids Sphingolipid Rats Disease Models Animal Endocrinology medicine.symptom General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 58:4084-4089 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Acetic acid bacteria, fermentative microorganisms of traditional foods, have unique alkali-stable lipids (ASL), such as dihydroceramide which is a precursor of sphingolipids. Sphingolipids are important components of the brain tissue. We examined the effect of oral administration of ASL in a rat model of dementia (7-week-old, male) with a basal forebrain lesion. In a water maze test, the dementia model rats demonstrated poor spatial orientation. The administration of ASL (165 or 1650 mg/kg of body weight per day, for 14 days) produced a significant improvement in learning ability in the dementia model rats. In vitro experiments showed ASL had the ability to promote neurite outgrowth in pheochromocytoma (PC12) cells. Among the ASL components, dihydroceramide has the most potent effect on the differentiation of PC12 cells. It is highly possible that oral administration of dihydroceramide-containing ASL reverses the decline in cognitive function in dementia. |
| Databáze: | OpenAIRE |
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