Fluoride doped γ-Fe2O3nanoparticles with increased MRI relaxivity
| Autor: | B. R. G. Johnson, Stephen J. Archibald, David J. Evans, Heiko Wende, P. Gibbs, M. G. Francesconi, Soma Salamon, M. Pickles, C. A. Burnett, L. Lazzarini, N. E. Jones, Joachim Landers |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
MRI contrast agent IRON-OXIDE NANOPARTICLES POTENTIAL CLINICAL-APPLICATIONS MAGNETITE MAGHEMITE SURFACE AGENTS PHASE PET Biomedical Engineering Nanoparticle 02 engineering and technology General Chemistry General Medicine Coercivity 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Magnetic anisotropy chemistry.chemical_compound Magnetization Nuclear magnetic resonance chemistry Mössbauer spectroscopy General Materials Science 0210 nano-technology Fluoride Iron oxide nanoparticles |
| Zdroj: | Journal of Materials Chemistry B 6 (2018): 3665–3673. doi:10.1039/c8tb00360b info:cnr-pdr/source/autori:Jones, N. E.; Burnett, C. A.; Salamon, S.; Landers, J.; Wende, H.; Lazzarini, L.; Gibbs, P.; Pickles, M.; Johnson, B. R. G.; Evans, D. J.; Archibald, S. J.; Francesconi, M. G./titolo:Fluoride doped gamma-Fe2O3 nanoparticles with increased MRI relaxivity/doi:10.1039%2Fc8tb00360b/rivista:Journal of Materials Chemistry B/anno:2018/pagina_da:3665/pagina_a:3673/intervallo_pagine:3665–3673/volume:6 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described by its longitudinal and transverse relaxivities, r(1) and r(2). gamma-Fe2O3 nanoparticles -doped with fluoride in a controlled manner and functionalised with citric acid showed a 3-fold increase in r(1) and a 17-fold increase in r(2) in a magnetic field of 3 T and almost 6-fold increase in r(1) and a 14-fold increase in r(2) at 11 T. Following fluorination, PXRD shows that the crystal structure of g-Fe2O3 is maintained, Mossbauer spectroscopy shows that the oxidation state of the Fe cation is unchanged and HREM shows that the particle size does not vary. However, magnetisation curves show a large increase in the coercive field, pointing towards a large increase in the magnetic anisotropy for the fluorinated nanoparticles compared to the un-doped g-Fe2O3 nanoparticles. Therefore, a chemically induced increase in magnetic anisotropy appears to be the most relevant parameter responsible for the large increase in relaxivity for gamma-Fe2O3 nanoparticles. |
| Databáze: | OpenAIRE |
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