Different methods of enhancing the efficacy of topical tacrolimus in extra‐facial vitiligo: A comparative study
| Autor: | Samia Esmat, Eman R Said, Farah Sayed Ahmed, Rehab A. Hegazy, Heba I. Gawdat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Vitiligo Dermatology Tacrolimus 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Occlusion medicine Humans skin and connective tissue diseases Pigmentation disorder Adult patients business.industry Significant difference Topical tacrolimus medicine.disease Treatment Outcome surgical procedures operative Minimal effect Face 030220 oncology & carcinogenesis Female business Pigmentation Disorders |
| Zdroj: | Journal of Cosmetic Dermatology. 20:3545-3551 |
| ISSN: | 1473-2165 1473-2130 |
| Popis: | Background Vitiligo is an acquired pigmentation disorder due to loss of melanocytes. Topical tacrolimus is effective in vitiligo treatment with minimal effect on extra-facial lesions. Objective To assess different methods of enhancing the absorption of topical tacrolimus in extra-facial vitiligo sites using microneedling and occlusion. Methods This study included 20 adult patients of both sexes with non-segmental vitiligo. Four extra-facial vitiligo lesions in each patient were randomly labeled A, B, C, and D and treated as follows: area A: tacrolimus ointment (0.03%) application twice/day, area B: microneedling once/week and tacrolimus ointment application directly after microneedling and twice/day the rest of the week, area C: microneedling once/week alone, and area D: tacrolimus ointment application twice/day under occlusion by polyethylene foil. The evaluation was done clinically by calculating the re-pigmentation percent after 6 months of treatment. Results Responders in area B were 45%, and 35% in area C, and 25% in both areas A and D. No statistically significant difference was detected regarding the re-pigmentation percent between the four areas (p > 0.05). No correlations were detected between re-pigmentation percent and patients' data. Conclusion Combination of microneedling and topical tacrolimus has an edge over monotherapy in vitiligo, and further studies are needed to verify such results. |
| Databáze: | OpenAIRE |
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