Nanoparticle Properties Influence Transendothelial Migration of Monocytes

Autor:	Nahal Habibi, Tyler D. Brown, Kwasi Adu-Berchie, Stephanie Christau, Jeffery E. Raymond, David J. Mooney, Samir Mitragotri, Joerg Lahann
Rok vydání:	2022
Předmět:	Integrins Transendothelial and Transepithelial Migration Transferrin Electrochemistry Endothelial Cells Humans Nanoparticles General Materials Science Surfaces and Interfaces Condensed Matter Physics Monocytes Spectroscopy
Zdroj:	Langmuir. 38:5603-5616
ISSN:	1520-5827 0743-7463
DOI:	10.1021/acs.langmuir.2c00200
Popis:	Nanoparticle-based delivery of therapeutics to the brain has had limited clinical impact due to challenges crossing the blood-brain barrier (BBB). Certain cells, such as monocytes, possess the ability to migrate across the BBB, making them attractive candidates for cell-based brain delivery strategies. In this work, we explore nanoparticle design parameters that impact both monocyte association and monocyte-mediated BBB transport. We use electrohydrodynamic jetting to prepare nanoparticles of varying sizes, compositions, and elasticity to address their impact on uptake by THP-1 monocytes and permeation across the BBB. An
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a3d5ece60ad11f54c339a4d68411bc https://doi.org/10.1021/acs.langmuir.2c00200 Zobrazit plný text záznamu