Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma
| Autor: | Chen Chen, Fei Wang, Lei Wang, Fen Li, Anyuan Zheng, Yong Xu, Yong Han, Bokui Xiao, Zezhang Tao, Zhangwei Hu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research head and neck squamous cell carcinoma Metastasis 03 medical and health sciences Gene Expression Omnibus dataset 0302 clinical medicine stomatognathic system otorhinolaryngologic diseases Medicine metastasis neoplasms biology Oncogene business.industry ferritin Cancer Articles medicine.disease Molecular medicine Head and neck squamous-cell carcinoma Ferritin Ferritin light chain stomatognathic diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Biomarker (medicine) biomarker business |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, yet current treatment options are associated with limited success. The aim of the present study was to investigate the expression of ferritin in HNSCC and clarify whether it may serve as a biomarker for predicting HNSCC metastasis. The chemiluminescent immunoassay method was used to investigate the differences in the serum ferritin (SF) levels between patients with and without tumors, and between HNSCC with and without lymph node metastasis. The iron content and expression levels of ferritin were detected to verify the differences between tumor and normal tissues, and between HNSCC without and with lymph node metastasis. Data from the Gene Expression Omnibus (GEO) dataset was used to support the aforementioned results. No statistically significant difference in the SF level was observed between patients with and without tumors. Iron content and expression levels of ferritin heavy chain (FTH) and ferritin light chain (FTL) were higher in tumor tissues compared with normal tissues. The iron content and expression levels of SF, FTH and FTL were increased in HNSCC with metastasis compared with HNSCC without metastasis. The GEO dataset further verified the results and reported that the expression level of FTH was correlated with the prognosis of patients with HNSCC. Ferritin may not be a biomarker for the early diagnosis of HNSCC. However, an association exists between the expression level of ferritin and HNSCC cervical metastasis. SF may be a potential biomarker for predicting cervical lymph node metastasis in patients with HNSCC. |
| Databáze: | OpenAIRE |
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