Prognostic value of admission serum magnesium in acute myocardial infarction complicated by malignant ventricular arrhythmias
| Autor: | Kiwamu Kamiya, Kenjiro Kikuchi, Sakae Takenaka, Tomoya Sato, Toshihisa Anzai, Kazunori Omote, Toshiyuki Nagai, Yoshifumi Mizuguchi, Hiroyuki Iwano, Atsushi Tada, Takuma Sato, Yuta Kobayashi, Hirokazu Komoriyama, Yoshiya Kato, Shingo Tsujinaga, Shinya Tanaka, Takao Konishi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Myocardial Reperfusion Hospitals University 03 medical and health sciences 0302 clinical medicine Primary outcome Predictive Value of Tests Risk Factors Internal medicine medicine Humans Magnesium In patient Hospital Mortality cardiovascular diseases Myocardial infarction Adverse effect Aged Retrospective Studies Surrogate endpoint business.industry Percutaneous coronary intervention 030208 emergency & critical care medicine General Medicine Magnesium level Middle Aged Prognosis medicine.disease chemistry Ventricular Fibrillation Tachycardia Ventricular Emergency Medicine Cardiology Female business Biomarkers Out-of-Hospital Cardiac Arrest |
| Zdroj: | The American Journal of Emergency Medicine. 44:100-105 |
| ISSN: | 0735-6757 |
| Popis: | Although electrolyte abnormalities are related to worse clinical outcomes in patients with acute myocardial infarction (AMI), little is known about the association between admission serum magnesium level and adverse events in AMI patients complicated by out-of-hospital cardiac arrest presenting with malignant ventricular arrhythmias (OHCA-MVA). We investigated the prognostic value of serum magnesium level on admission in these patients.We retrospectively analyzed the data of 165 consecutive reperfused AMI patients complicated with OHCA-MVA between April 2007 and February 2020 in our university hospital. Serum magnesium concentration was measured on admission. The primary outcome was in-hospital death.Fifty-four patients (33%) died during hospitalization. Higher serum magnesium level was significantly related to in-hospital death (FineGray's test; p 0.001). In multivariable logistic regression analyses, serum magnesium level on admission was independently associated with in-hospital death (hazard ratio 2.68, 95% confidence interval 1.24-5.80) even after adjustment for covariates. Furthermore, the incidences of cardiogenic shock necessitating an intra-aortic balloon pump (p = 0.005) or extracorporeal membrane oxygenation (p 0.001), tracheal intubation (p 0.001) and persistent vegetative state (p = 0.002) were significantly higher in patients with higher serum magnesium level than in those with lower serum magnesium level.In reperfused AMI patients complicated by OHCA-MVA, admission serum magnesium level might be a potential surrogate marker for predicting in-hospital death. |
| Databáze: | OpenAIRE |
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