Decreased numbers of circulating plasmablasts and differences in IgA1-plasmablast homing to skin in coeliac disease and dermatitis herpetiformis
| Autor: | T. Reunala, Heikki Arvilommi, M. Westerholm-Ormio, Anu Kantele, Erkki Savilahti, Sari H. Pakkanen, Jussi M. Kantele |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Translational Studies Tissue transglutaminase Dermatitis Herpetiformis Plasma Cells Immunology Receptors Lymphocyte Homing digestive system Coeliac disease Young Adult 03 medical and health sciences 0302 clinical medicine Antigen Immunopathology Dermatitis herpetiformis medicine Humans Immunology and Allergy Enteropathy Intestinal Mucosa Immunity Mucosal Skin 030304 developmental biology Autoimmune disease 0303 health sciences biology business.industry Cell Differentiation Middle Aged medicine.disease Immunoglobulin A 3. Good health Celiac Disease Immunoglobulin M Immunoglobulin G 030220 oncology & carcinogenesis biology.protein Female business Homing (hematopoietic) |
| Zdroj: | Clinical and Experimental Immunology. 156:535-541 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2009.03922.x |
| Popis: | SummaryThe two clinical phenotypes of gluten enteropathy, coeliac disease (CD) and dermatitis herpetiformis (DH), were characterized for numbers and homing profiles of circulating final effector B cells, plasmablasts, identified as immunoglobulin (Ig)-secreting cells (ISC). In CD, the numbers of ISC were ∼50% lower than in DH or controls. ISC expressed peripheral lymph node homing receptor (HR), L-selectin, less frequently in CD (54%) and DH (52%) patients than in controls (70%). The expression of gut mucosal HR, α4β7, was less frequent in CD (42%) than in DH (65%) or controls (60%). In DH, but not in CD or controls, a higher proportion of IgA1-ISC (40%) than IgA2-ISC (25%) expressed the skin HR, cutaneous lymphocyte-associated antigen. In gluten enteropathy circulating plasmablasts are more mature, but decreased in number, and have distorted homing profiles. Differential IgA1-plasmablast homing could be associated with the development of skin rash with IgA1-deposits in DH but not in CD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|