Family history of stroke in stroke types and subtypes
| Autor: | I.C. Metallinos, N.P. Lekka, Th. Papapetropoulos, G Gioldasis, John Ellul, Christos Paschalis, Panagiotis Polychronopoulos |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Disease Intracranial Hemorrhage Hypertensive Brain Ischemia Diabetes Complications Central nervous system disease Sex Factors Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Humans Medicine cardiovascular diseases Risk factor Family history Stroke Aged Family Health Greece business.industry Vascular disease Smoking Age Factors Middle Aged medicine.disease Confidence interval Surgery Neurology Hypertension Female Neurology (clinical) business |
| Zdroj: | Journal of the Neurological Sciences. 195:117-122 |
| ISSN: | 0022-510X |
| Popis: | Many studies have provided data showing that family history of stroke (FHS) is associated with an increased risk of stroke. The association of the FHS with the various stroke subtypes has not been adequately studied. The purpose of this study was to assess the association of the FHS with the two major stroke types (cerebral haematomas and ischaemic strokes) and the four stroke subtypes (cardioembolic, large artery disease, small artery disease, and undetermined) in a Greek population. The FHS was obtained from 421 consecutive acute stroke patients and from 239 matched control subjects. Positive FHS was observed in 49% of all stroke patients compared with 28% of the control subjects [adjusted OR=2.06 (95% confidence intervals (CI) 1.42-3.00)]. Haematomas, ischaemic strokes, and from the ischaemic strokes, both large and small artery disease strokes were strongly associated with positive FHS compared with the control subjects [adjusted OR=2.06 (95% CI 9-3.04), 2.07 (95% CI 1.09-3.91), 2.05 (95% CI 1.24-3.38), and 2.76 (95% CI 1.55-4.91), respectively]. There was no difference between maternal and paternal heritable contribution.In conclusion, FHS was found in this study to be an independent risk factor for all strokes combined, for each stroke type, and for the large and small-artery disease stroke subtypes, but not for the cardioembolic and undetermined stroke subtypes. |
| Databáze: | OpenAIRE |
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