TETRAHYDRO-?-CARBOLINES: SPECIFIC INHIBITORS OF TYPE A MONOAMINE OXIDASE IN RAT BRAIN
| Autor: | Emanuel Meller, Arnold J. Friedhoff, Jack W. Schweitzer, Eitan Friedman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Serotonin Phenethylamine Indoles Monoamine Oxidase Inhibitors Monoamine oxidase Hypothalamus Deamination Brain Oxidative deamination Pharmacology Biochemistry Rats Kinetics Cellular and Molecular Neuroscience chemistry.chemical_compound chemistry Phenethylamines Type A Monoamine Oxidase Animals Monoamine oxidase B Carbolines |
| Zdroj: | Journal of Neurochemistry. 28:995-1000 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1977.tb10661.x |
| Popis: | — A series of serotonin and phenethylamine analogs were tested for their ability to differentially inhibit type A or B monoamine oxidase (EC 1.4.3.4) in rat hypothalamus. The most specific and potent effects were shown by several tetrahydro-β-carbolines which competitively inhibited the oxidative deamination of serotonin at micromolar concentrations. In contrast, effective inhibition of phenethylamine deamination was observed only at or near millimolar concentrations of these drugs. Significant reductions of type A but not type B MA0 activity were also observed after administration of 25–100 mg/kg, i.p., of tetrahydro-β-carboline and its 6-methoxy derivative. |
| Databáze: | OpenAIRE |
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