Expression of growth factors and their receptors in the primary renal cell carcinoma: new data and review
| Autor: | Saida Ashuba, Dmitry Khochenkov, Vsevolod Matveev, Yulia Khochenkova, Anna Sergeevna Olshanskaya, Elyso Solomko, Maria Volkova, Ilya Tsimafeyeu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Original Paper
renal cell carcinoma Platelet-derived growth factor biology vascular endothelial growth factor business.industry Fibroblast growth factor receptor 1 General Medicine Fibroblast growth factor Receptor tyrosine kinase Vascular endothelial growth factor platelet-derived growth factor chemistry.chemical_compound primary tumor Growth factor receptor chemistry fibroblast growth factor Cancer research biology.protein Medicine business Receptor Platelet-derived growth factor receptor |
| Zdroj: | Central European Journal of Urology |
| ISSN: | 2080-4873 2080-4806 |
| Popis: | Introduction The aim of our study was to investigate expression levels and the prognostic value of multiple growth factors and their receptors in the primary tumor cells of renal cell carcinoma (RCC). Material and methods Expression of vascular endothelial growth factor (VEGF)A, fibroblast growth factor (FGF)2, vascular endothelial growth factor receptor (VEGFR)1, VEGFR2, FGFR1, FGFR2, platelet-derived growth factor receptor (PDGFR)α, and PDGFRβ was investigated in 65 primary RCC specimens by immuhistochemical staining using the appropriate antibodies. Expression levels were evaluated by the semi-quantitative method. A search for correlations of expression levels of investigated growth factors and receptors with RCC features and patients outcomes was performed. Results Expression of all growth factors and their receptors was detected both on the surface and in the cytoplasm of the primary tumor cells in RCC patients. The expression of all analyzed factors was interconnected. FGFR2 expression correlated with the largest number of other growth factors and receptors. A strong correlation was revealed between high expression of the studied markers, high Fuhrman grade, and advanced RCC stages. In a univariate analysis overexpression of VEGFR2 (p |
| Databáze: | OpenAIRE |
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