Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia

Autor:	Ernst Ulsperger, Elmir Graf, Reinhard Stauder, Eva Jäger, Klaus Geissler, Heinz Tüchler, Josef Thaler, Ulrich Germing, Peter Valent, Ansgar Weltermann, Christoph Geissler, Sonja Heibl, Renate Marschon, Agnes Barna, Armin Zebisch, Michael Pfeilstöcker, Leopold Öhler, Rajko Kusec, Otto Zach, Bruno Schneeweiss, Michael Gurbisz, Temeida Graf, Peter Bettelheim, Heinz Sill, Sigrid Machherndl-Spandl, Gerald Webersinke, Gregor Hoermann, Thomas Nösslinger
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult Male medicine.medical_specialty blast cell count Leukemia Myelomonocytic Chronic / epidemiology Leukemia Myelomonocytic Chronic / mortality Comorbidity Lower risk Competing risks Myelomonocytic leukaemia cytogenetics 03 medical and health sciences 0302 clinical medicine Older patients Internal medicine hemic and lymphatic diseases Biomarkers Tumor Odds Ratio Medicine score Humans In patient Aged Aged 80 and over Leukemia Myelomonocytic Chronic / etiology business.industry Age Factors Leukemia Myelomonocytic Chronic Hematology General Medicine Original Articles Middle Aged mutations Prognosis Peripheral blood Leukemia Myelomonocytic Chronic / pathology Cumulative risk age 030220 oncology & carcinogenesis Health Impact Assessment Life expectancy Disease Progression Original Article Female Disease Susceptibility business chronic myelomonocytic leukaemia 030215 immunology
Zdroj:	European Journal of Haematology
ISSN:	1600-0609 0902-4441
Popis:	In older patients with chronic myelomonocytic leukaemia (CMML) and limited life expectancy due to age and or comorbidities, it is particularly important to consider the risk of transformation for individualised treatment decisions. There is limited information on potential differences between younger and older CMML patients regarding the cumulative risk of transformation as well as haematological, molecular and biologic characteristics. We analysed data from the Austrian Biodatabase for CMML (ABCMML) to compare these parameters in 518 CMML patients. Categorisation of patients into 3 age‐related groups
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0499bf4bc452a507e0fef47b6ab23a47 http://europepmc.org/articles/PMC8480146 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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