Polymorphonuclear Leukocyte Activation
| Autor: | C. H. Wakefield, Sharmila Foulds, John R. T. Monson, Pierre J. Guillou, P. Declan Carey |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils Complement receptor Granulocyte Sepsis chemistry.chemical_compound Antigens CD medicine Humans Surgical Wound Infection In patient Hydrogen peroxide Aged Retrospective Studies Aged 80 and over Polymorphonuclear leukocyte biology CD11 Antigens business.industry Bacterial Infections Hydrogen Peroxide Postoperative sepsis Middle Aged medicine.disease Surgery medicine.anatomical_structure chemistry Integrin alpha M biology.protein Female business Biomarkers |
| Zdroj: | Archives of Surgery. 128:390 |
| ISSN: | 0004-0010 |
| Popis: | It has been suggested that major surgery induces polymorphonuclear leukocyte (PMNL) dysfunction, which exposes patients to the development of sepsis. Conversely, the sepsis response and multisystem organ failure in patients after surgery is thought to be mediated by activated PMNLs. In a preliminary attempt to investigate this paradox, we studied functional (hydrogen peroxide production) and phenotypic (the adhesion/complement receptor CD11b) markers of PMNL activation in 28 patients undergoing elective major resectional surgery; 11 (39%) of these patients developed postoperative sepsis (the septic group). The mean (SEM) preoperative level of neutrophil CD11b expression (97.8 [6.2] mean channel fluorescence [MCF] and 101.42 [7.9] MCF; P = .74) and hydrogen peroxide production (109.51 [4.91] MCF and 104.53 [6.3] MCF; P = .5) were similar for the uncomplicated and septic groups, respectively. However, on the first postoperative day, both mean CD11b expression and hydrogen peroxide production were greater in those patients who subsequently developed postoperative sepsis (192.5 [38] MCF vs 128.6 [8.1] MCF for the septic group vs the uncomplicated group, respectively [P.05], and 120.43 [2.56] MCF vs 109.61 [3.05] MCF for the septic group vs the uncomplicated group, respectively [P.0001]). We suggest that an exaggerated PMNL activation response to surgery is an early event in those patients destined to develop postsurgical sepsis. |
| Databáze: | OpenAIRE |
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