Does isoflurane optimize myocardial protection during cardiopulmonary bypass?
| Autor: | Sania Haroun-Bizri, Anis Baraka, Imad Rachid Chehab, Samar S. Khoury, Chadi Kassas |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Ischemia Cardiac index Hemodynamics Myocardial Reperfusion Injury law.invention Electrocardiography Postoperative Complications law Internal medicine Cardiopulmonary bypass medicine Humans Prospective Studies Derivation Cardiac Output Coronary Artery Bypass Cardiopulmonary Bypass Isoflurane business.industry Arrhythmias Cardiac Middle Aged medicine.disease Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Anesthetics Inhalation Ischemic Preconditioning Myocardial Cardiology Ischemic preconditioning Female Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia. 15:418-421 |
| ISSN: | 1053-0770 |
| Popis: | Objective: To investigate the possible myocardial protective effect of isoflurane during aortic cross-clamp and cardioplegic cardiac arrest in patients undergoing conventional coronary artery bypass graft surgery. Design: Prospective, randomized. Setting: University medical center. Participants: Forty-nine patients undergoing elective coronary artery bypass graft surgery divided into 2 groups: control group (n = 21) and isoflurane group (n = 28). Intervention: Isoflurane was administered in the pre-cardiopulmonary bypass (CPB) period to the isoflurane group. Measurements And Main Results: Hemodynamics and ST- segment variations were monitored in the pre-CPB period and after weaning from CPB in both groups. Incidence of reperfusion arrhythmias after release of aortic cross-clamp was compared. In the isoflurane group, the mean cardiac index after CPB was significantly higher than the pre-CPB value, whereas no difference between the 2 values was found in the control group. The higher cardiac index in the isoflurane group was associated with a lesser degree of ST- segment changes than in the control group. There was no significant difference between the 2 groups in the incidence of reperfusion arrhythmias after release of aortic cross-clamp. Conclusion: The present report suggests that administration of isoflurane before aortic cross-clamping in patients undergoing coronary artery bypass graft surgery may optimize the myocardial protective effect of cardioplegia. Isoflurane may be particularly advantageous whenever prolonged periods of aortic cross-clamping or inadequate delivery of cardioplegia is expected. Copyright © 2001 by W.B. Saunders Company |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect