Voluntary exercise increases IgA concentration and polymeric Ig receptor expression in the rat submandibular gland
| Autor: | Juri Saruta, Keiichi Tsukinoki, Yuko Yamamoto, Yuki Kurimoto, Masahiro To, Koji Kimura |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Immunoglobulin A Saliva medicine.medical_specialty Receptor expression Submandibular Gland Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Physical Conditioning Animal Internal medicine medicine Animals Secretion RNA Messenger Rats Wistar Receptor Molecular Biology Regulation of gene expression biology Body Weight Organic Chemistry Receptors Polymeric Immunoglobulin 030229 sport sciences General Medicine Submandibular gland Rats 030104 developmental biology Endocrinology medicine.anatomical_structure Gene Expression Regulation biology.protein Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 80:2490-2496 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1080/09168451.2016.1217145 |
| Popis: | Salivary IgA—a primary factor in local immunity of the oral cavity—plays an important role in maintaining local immune function in the oral cavity and prevent upper respiratory tract infections. Oral IgA levels are known to fluctuate in an exercise-dependent manner; thus, we investigated the effects of voluntary exercise on salivary IgA secretion in rats to better understand the mechanism by which this occurs. Six-week-old male Wistar rats were placed in individual cages with or without access to exercise wheels for three weeks. Notably, animals who engaged in voluntary exercise demonstrated significant increases in IgA concentration in saliva and submandibular gland tissue, as well as a markedly higher salivary IgA flow rate. Moreover, active rats also exhibited elevated polymeric Ig receptor (pIgR) mRNA expression in submandibular gland tissue. Collectively, these results suggest that voluntary exercise may increase salivary IgA concentration and boost immune function in the oral cavity. |
| Databáze: | OpenAIRE |
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