The activation of phosphatidylinositol turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors
| Autor: | Giovanni Fontana, Paolo Paudice, Maurizio Raiteri, Mario Marchi |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Dopamine Bethanechol Biology Phosphatidylinositols Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine Muscarinic acetylcholine receptor medicine Oxotremorine Animals Phosphatidylinositol Neurotransmitter Acetylcholine receptor Cerebral Cortex Neurotransmitter Agents Rats Inbred Strains General Medicine Receptors Muscarinic Acetylcholine Rats Endocrinology chemistry medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf00970760 |
| Popis: | In the rat cerebral cortex, the comparative effects of various muscarinic agonists on the release of [3H]dopamine ([3H]DA), [3H]acetylcholine ([3H]ACh), and [3H]5-hydroxytryptamine ([3H]5-HT) from superfused nerve endings and on phosphatidylinositol (PI) turnover were studied. Acetylcholine (ACh) was found to be the most potent among the agonists tested on all three release systems examined, and also on the activation of PI turnover. Oxotremorine and bethanechol were very weak agonists when tested as stimulators of PI turnover. However, oxotremorine was very effective as a release modulator, while bethanechol was completely ineffective. Our data suggest that the activation of PI turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors. |
| Databáze: | OpenAIRE |
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