Relationship between neutrophil-lymphocyte ratio and severity of lower extremity peripheral artery disease
| Autor: | Anvar Babaev, Yu Guo, Jacob Teperman, Binita Shah, David Carruthers, Adam A. Harris, Cezar Staniloae, Steven P. Sedlis, Mallory P. Barnett, Michael J. Attubato, Michael H. Pillinger |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils 030204 cardiovascular system & hematology Severity of Illness Index Article Coronary artery disease Peripheral Arterial Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Predictive Value of Tests Internal medicine Diabetes mellitus medicine Humans Lymphocyte Count Lymphocytes 030212 general & internal medicine Aged Retrospective Studies Aged 80 and over Creatinine business.industry Endovascular Procedures Angiography Odds ratio Middle Aged medicine.disease Confidence interval Surgery Lower Extremity chemistry Cohort Cardiology Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Int J Cardiol |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2016.11.097 |
| Popis: | Background The aim of this study was to determine the association between neutrophil-lymphocyte ratio (NLR) and severity of lower extremity peripheral artery disease (PAD). Methods A retrospective chart review identified 928 patients referred for peripheral angiography. NLR was assessed from routine pre-procedural hemograms with automated differentials and available in 733 patients. Outcomes of interest were extent of disease on peripheral angiography and target vessel revascularization. Median follow-up was 10.4months. Odds ratio (OR) [95% confidence intervals] was assessed using a logistic regression model. Results There was a significant association between elevated NLR and presence of severe multi-level PAD versus isolated suprapopliteal or isolated infrapopliteal disease (OR 1.11 [1.03–1.19], p =0.007). This association remained significant even after adjustment for age (OR 1.09 [1.01–1.17], p =0.02); age, sex, race, and body mass index (OR 1.08 [1.00–1.16], p =0.046); and age, sex, race, body mass index, hypertension, diabetes mellitus, coronary artery disease, and creatinine (OR 1.07 [1.00–1.15], p =0.049). After additional adjustment for clinical presentation, there was a trend towards association between NLR and severe multi-level PAD (OR 1.07 [1.00–1.15], p =0.056), likely limited by sample size. In patients who underwent endovascular intervention (n=523), there was no significant difference in rate of target vessel revascularization across tertiles of NLR (1st tertile 14.8%, 2nd tertile 14.1%, 3rd tertile 20.1%; p =0.32). Conclusion In a contemporary cohort of patients undergoing peripheral angiography with possible endovascular intervention, elevated NLR was independently associated with severe multi-level PAD. Larger studies evaluating the association between this inexpensive biomarker and clinical outcomes are warranted. |
| Databáze: | OpenAIRE |
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