HPA polymorphism in sub-Saharan African populations: Beninese, Cameroonians, Congolese, and Pygmies
| Autor: | Cécile Kaplan, E. Julien, G. Mulen-Imandy, F. Bianchi, L. Y. Anani, C. Martageix, G. Jaeger, A. Bigot, K. Mbayo, L. Halle |
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| Rok vydání: | 2005 |
| Předmět: |
endocrine system
education.field_of_study Polymorphism Genetic Sub saharan Immunology Population Black People Context (language use) Human platelet General Medicine Biochemistry Isolated population Geography Gene Frequency Polymorphism (computer science) parasitic diseases Genetics Humans Immunology and Allergy Antigens Human Platelet education Socioeconomics Africa South of the Sahara hormones hormone substitutes and hormone antagonists AKA |
| Zdroj: | Tissue Antigens. 65:295-298 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.2005.00360.x |
| Popis: | The frequency of human platelet antigen-1 (HPA-1) to HPA-11w (excluding HPA-8w) and HPA-15 systems was studied in four sub-Saharan populations: Beninese, Congolese (Democratic Republic of Congo Kinshasa), Cameroonians, and Aka pygmies (Central African Republic). No report of HPA prevalence has previously been published concerning these populations which are characterized by the highest HPA-2b gene frequencies of any reported to date (Aka 0.393, Benin 0.292, Cameroon 0.237, and Congo 0.224) and at lesser degree HPA-5b (Aka 0.405, Congo 0.268, Cameroon 0.254, and Benin 0.182). This study is of great importance (i) particularly in the context of the diversity caused by the population migrations, we may observe today in our hospitals (ii) to confirm that the Pygmy population with distinctive frequencies (absence of the HPA-1b, HPA-2b, and HPA-5b highest frequencies) is an isolated population. |
| Databáze: | OpenAIRE |
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