Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients
| Autor: | S. Barathi, R Sivaramakrishna, T Seethalakshmi, Narayanasamy Angayarkanni, R Punitham, S Tarun, G Suganeswari |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Hyperhomocysteinemia Homocysteine Gastroenterology Thiobarbituric Acid Reactive Substances Arylesterase chemistry.chemical_compound Young Adult Risk Factors Internal medicine Retinal Vein Occlusion TBARS Medicine Humans Prospective cohort study biology business.industry Aryldialkylphosphatase Paraoxonase medicine.disease PON1 Surgery Ophthalmology Oxidative Stress chemistry Case-Control Studies biology.protein Female business Carboxylic Ester Hydrolases |
| Zdroj: | Eye (London, England). 22(7) |
| ISSN: | 0950-222X |
| Popis: | To estimate the arylesterase activity of serum paraoxonase-1 (PON1-ARE), which is reported to have an antioxidant and antiatherogenic potential and to correlate with plasma homocysteine (Hcys) and plasma TBARS in young adult central retinal venous occlusion (CRVO) patients.A case-control prospective study carried out in 10 CRVO patients (mean age 27+/-5 years; 7 males, 3 females) and 20 healthy controls (mean age 29+/-5 years; 15 males, 5 females).The CRVO patients showed a significantly lowered serum PON1-ARE activity (P=0.009) along with a significant increase in the levels of plasma Hcys (P=0.018) when compared to the control subjects. There was a negative correlation between serum PON1-ARE and plasma Hcys levels (P=0.058) as well as between PON1-ARE and plasma TBARS levels (P=0.001) in the CRVO patients.This is the first report of lowered serum PON1-ARE level as a risk factor for CRVO (OR= 1.108, CI=0.914, 1.314; P=0.296), which is found to correlate with oxidative stress. |
| Databáze: | OpenAIRE |
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