Acid secretory responses and parietal cell sensitivity following duodenal ulcer healing with omeprazole, sucralfate, and Maalox
| Autor: | David A. Johnston, Sharon Bridger, Marks In, John Zak, Gerry O. Young, Nel A. Tigler-Wybrandi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnesium Hydroxide medicine.medical_treatment Sucralfate Stimulation Aluminum Hydroxide Gastroenterology Endoscopy Gastrointestinal Gastric Acid Basal (phylogenetics) Parietal Cells Gastric Recurrence Internal medicine Gastrins medicine Humans Omeprazole Parietal cell Aged Chemotherapy Wound Healing business.industry General Medicine Metabolism Fasting Gastric Acidity Determination Middle Aged Pentagastrin Drug Combinations medicine.anatomical_structure Duodenal Ulcer Female Antacids business medicine.drug |
| Zdroj: | The American journal of medicine. 91(2A) |
| ISSN: | 0002-9343 |
| Popis: | Acid secretory responses and parietal cell sensitivity (PCS) have been studied in 21 duodenal ulcer patients before and after successful treatment with omeprazole (n = 7), sucralfate (n = 7), or Maalox (n = 7). The second study was carried out 3 days after documented healing and withdrawal of treatment in the sucralfate- and Maalox-treated groups and 14 days after documented healing and withdrawal of treatment in the omeprazole-treated patients. Acid output (mmol/hour) was measured as basal secretion, and in response to 0.1 microgram/kg/hour pentagastrin (low-dose) and 6.0 micrograms/kg/hour pentagastrin (high-dose) stimulation. PCS was calculated as the ratio of low dose:high dose acid output (expressed as a percentage). Ulcer healing with sucralfate resulted in significant (p less than 0.05) decreases in low-dose acid output from 36.4% (13.2-51.0) (median [range]) to 8.4% (3.2-45.4) mmol/hour and PCS from 69.1% (44.9-91.4) to 22.0% (16.0-85.6), whereas no significant decreases in any of the measured parameters were noted following ulcer healing with Maalox. Ulcer healing with omeprazole resulted in significant (p less than 0.05) decreases in basal acid output from 6.3 (1.5-22.9) (median [range]) to 2.2 (0-6.9) mmol/hour, and low-dose acid output from 31.0 (6.0-58.0) to 23.0 (1.4-44.8) mmol/hour. These findings suggest that acid secretory responses following ulcer healing vary according to the therapeutic agent used. |
| Databáze: | OpenAIRE |
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