Sericin and swimming on histomorphometric parameters of denervated plantar muscle in Wistar rats
| Autor: | Ana Luiza Peretti, André Junior Santana, Regina Inês Kunz, Gladson Ricardo Flor Bertolini, Pâmela Buratti, Jean Carlos Debastiani, Márcia Miranda Torrejais, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Swimming exercise Nerve Crush Exercício Wistar lcsh:Medicine Connective tissue Physical exercise Fibras musculares esqueléticas Muscle damage Sericin Random Allocation 03 medical and health sciences Ratos Wistar 0302 clinical medicine Physical Conditioning Animal Internal medicine medicine Animals Rats Wistar Sericins Muscle fibre Muscle Skeletal Peripheral nerves Exercise Sciatic nerve/injuries Swimming business.industry lcsh:R Nervos periféricos Proteins 030229 sport sciences General Medicine skeletal Nervo isquiático/lesões Rats Muscle fibers Disease Models Animal medicine.anatomical_structure Endocrinology Lower Extremity Proteínas Peripheral nerve injury Original Article Sciatic nerve business human activities 030217 neurology & neurosurgery |
| Zdroj: | Einstein (São Paulo), Vol 16, Iss 1 Einstein einstein (São Paulo) v.16 n.1 2018 Einstein (São Paulo) Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
| ISSN: | 2317-6385 1679-4508 |
| Popis: | Objective To analyze the combined effects of the silk protein sericin and swimming exercise on histomorphometry of the plantar muscle in Wistar rats. Methods Forty adult rats were randomly allocated into 5 groups comprising 8 animals each, as follows: Control, Injury, Sericin, Swim, and Swim plus Sericin. Three days after crushing of the sciatic nerve the rats in the Swim and Swim plus Sericin Groups were submitted to swimming exercise for 21 days. Rats were then euthanized and the plantar muscle harvested and processed. Results Cross-sectional area, peripheral nuclei and muscle fiber counts, nucleus/fiber ratio and smallest muscle fiber width did not differ significantly between groups. Morphological analysis revealed hypertrophic fibers in the Swim Group and evident muscle damage in the Swim plus Sericin and Injury Groups. The percentage of intramuscular collagen was apparently maintained in the Swim Group compared to remaining groups. Conclusion Combined treatment with sericin and swimming exercise did not improve muscle properties. However, physical exercise alone was effective in maintaining intramuscular connective tissue and preventing progression of deleterious effects of peripheral nerve injury. |
| Databáze: | OpenAIRE |
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