Dysregulation of heart rhythm during sleep in leptin-deficient obese mice
| Autor: | Giovanna Zoccoli, Carlo Franzini, Pierluigi Lenzi, Viviana Lo Martire, Chiara Berteotti, Stefano Bastianini, Alessandro Silvani |
|---|---|
| Přispěvatelé: | Silvani A., Bastianini S., Berteotti C., Franzini C., Lenzi P., Lo Martire V., Zoccoli G. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Leptin
Male medicine.medical_specialty Sleep REM Adipokine Blood Pressure Baroreflex Autonomic Nervous System Electrocardiography Mice Heart Rate Physiology (medical) Internal medicine medicine Animals Obesity Circadian rhythm Wakefulness business.industry Heart Signal Processing Computer-Assisted Vagus Nerve Heart Rhythm in Sleep in Leptin-Deficient Obese Mice medicine.disease Sleep in non-human animals Disease Models Animal Autonomic nervous system Endocrinology Blood pressure cardiovascular system Sleep Stages Neurology (clinical) business psychological phenomena and processes Obesity leptin sleep autonomic nervous system heart rate blood pressure baroreflex |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | STUDY OBJECTIVES: sleep deeply affects cardiac autonomic control, the impairment of which is associated with cardiovascular mortality. Obesity entails increased cardiovascular risk and derangements in sleep and cardiac autonomic control. We investigated whether cardiac autonomic control is impaired during sleep in ob/ob mice with morbid obesity caused by congenital leptin deficiency. DESIGN: indexes of cardiac autonomic control based on spontaneous cardiovascular fluctuations were compared between ob/ob and lean wild-type (+/+) mice during wakefulness, non-rapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS). SETTING: N/A PATIENTS OR PARTICIPANTS: 7 ob/ob and 11 +/+ male mice. INTERVENTIONS: instrumentation with electrodes for sleep recordings and a telemetric transducer for measuring blood pressure and heart period. MEASUREMENTS AND RESULTS: In ob/ob mice, the variability of heart period and cardiac baroreflex sensitivity (sequence technique) were significantly lower than in +/+ mice during each wake-sleep state. The vagal modulation of heart period was significantly weaker in ob/ob than in +/+ mice during NREMS and REMS. In ob/ob mice, the cross-correlation function between heart period and blood pressure suggested that the baroreflex contribution to cardiac control was lower than in +/+ mice during wakefulness and NREMS, whereas the contribution of central autonomic commands was lower than in +/+ mice during NREMS and REMS. CONCLUSIONS: These data indicate a dysregulation of cardiac autonomic control during sleep in ob/ob mice. Ob/ob mice may represent a useful tool to understand the molecular pathways that lead to cardiac autonomic dysregulation during sleep in obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|