Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer
| Autor: | Liang Ma, Zi Liu, Gao-Feng Li, Ping Wang, Yi Cao, Hao-Bin Chen, Wenyi Gu, Zhaohui Gu, Shui-Wang He, Yongqiang Zhu, Zhi-Peng Hong, Yunchao Huang, Gui-Zhen Wang, Xiao-Lu Wang, Hui Kang, Xiao-Long Jin, Linwei Tian, Xiao-Hong Gao, Lichuan Wu, Shuting Chen, Yun-Dong Zhang, Jinyan Huang, Chun-Ming Pan, Xian-Jun Yu, Minjun Yang, Zhe-Sheng Wen, Hui Dong, Guang-Biao Zhou, Sai-Juan Chen, Shengyue Wang, Xin Cheng, Wen-Jing Mao, Bo O. Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Exome sequencing Mutation rate Lung Neoplasms Air pollution lcsh:Medicine Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Exposure chemistry.chemical_compound Carcinoma Non-Small-Cell Lung Benzo(a)pyrene medicine Humans Lung cancer Genetics Air Pollutants Mutation lcsh:R5-920 lcsh:R General Medicine Environmental exposure medicine.disease respiratory tract diseases chemistry Whole genome sequencing Original Article Female KRAS Carcinogenesis lcsh:Medicine (General) |
| Zdroj: | EBioMedicine, Vol 2, Iss 6, Pp 583-590 (2015) EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China attributed to severe air pollution generated by combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis of air pollution. Here we analyzed the somatic mutations of 164 non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used. Whole genome sequencing revealed a mean of 289 somatic exonic mutations per tumor and the frequent C:G → A:T nucleotide substitutions in Xuanwei NSCLCs. Exome sequencing of 2010 genes showed that Xuanwei and CR NSCLCs had a mean of 68 and 22 mutated genes per tumor, respectively (p Highlights • Somatic genomic mutations of air pollution-related lung cancer were characterized. • Mutations in air pollution-related lung cancers were 3 times as high as lung cancers from control regions. • 167 of the 2010 genes had higher mutation rates in patients from highly polluted region than those from control regions. • The mutation rates of 70 genes were associated with patients' lifetime benzo(a)pyrene exposure. |
| Databáze: | OpenAIRE |
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