Monthly Ibandronate for the Prevention of Bone Loss in Patients After Liver Transplantation
| Autor: | Gunter Wolf, M. Hommann, B. Schmidt, G. Lehmann, D. Kaemmerer, U. Settmacher |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors medicine.medical_treatment Osteoporosis Urology Administration Oral Liver transplantation Risk Assessment Drug Administration Schedule Fractures Bone Absorptiometry Photon Bone Density Risk Factors Germany medicine Humans In patient Prospective Studies Amino Acids Prospective cohort study Ibandronic Acid Cholecalciferol Femoral neck Bone mineral Transplantation Chi-Square Distribution Lumbar Vertebrae Bone Density Conservation Agents Diphosphonates Femur Neck business.industry Bone fracture Alkaline Phosphatase medicine.disease Liver Transplantation Surgery Osteopenia Bone Diseases Metabolic Treatment Outcome medicine.anatomical_structure Creatinine Dietary Supplements Calcium business Biomarkers |
| Zdroj: | Transplantation Proceedings. 44:1362-1367 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2012.01.133 |
| Popis: | Osteopenia and osteoporosis are diseases frequently occurring after liver transplantation (OLT).In a prospective study, we have investigated the effect of ibandronate, vitamin D(3), and calcium on the prevention and treatment of posttransplant osteopenia and osteoporosis.The bone mineral density (BMD) of the lumbar spine (LS) and of the femoral neck (FN) were measured in 74 patients prospectively pre- and post-OLT.Postoperatively the study group showed a consistent percentage increase in BMD (g/cm(2)) and a significantly increased BMD after 12 and 24 months in the LS (12 months: 1.05 ± 0.21 g/cm(2); P.001 24 months: 1.11 ± 0.19 g/cm(2); P.001) and the FN (12 months: 0.88 ± 0.16 g/cm(2); P.002 24 months: 0.90 ± 0.15 g/cm(2); P.001) in comparison with baseline pre-OLT (LS pre-OLT 0.98 ± 0.19 g/cm(2), FN 0.86 ± 0.14 g/cm(2)). The overall bone fracture rate was 5.4% up to 24 months.Ibandronate once monthly per os significantly increased the BMD in the LS and FN after OLT at 12 and 24 months. The increased BMD limits the risk of fracture. |
| Databáze: | OpenAIRE |
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