Designed symmetrical β-hairpin peptides for treating multidrug-resistant salmonella typhimurium infections

Autor:	Zhi Ma, Dong Zhang, Ziyi Cheng, Yandong Niu, Liangyu Kong, Zhaoxin Lu, Xiaomei Bie
Rok vydání:	2022
Předmět:	Salmonella typhimurium Lipopolysaccharides Pharmacology Salmonella Infections Organic Chemistry Drug Discovery Animals Humans General Medicine Peptides Anti-Bacterial Agents
Zdroj:	European Journal of Medicinal Chemistry. 243:114769
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2022.114769
Popis:	The rapid emergence and prevalence of multidrug-resistant salmonellosis lack effective therapies, which causes epidemic health problems and stimulates the development of antimicrobials with novel modes of action. In this research, 10 short symmetrical β-hairpin peptides are synthesized by combining the β-turn of Leucocin-A with recurring hydrophobic and cationic amino acid sequences. Those designed peptides exhibited potent antibacterial activities against drug-susceptible and drug-resistant Salmonella. One of the 10 peptides, WK2 ((WK)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048b065f9b9c2b232cfadbe747e789a3 https://doi.org/10.1016/j.ejmech.2022.114769 Zobrazit plný text záznamu Full Text from ScienceDirect