Assessment of liver fibrosis by transient elastography in young children with chronic hepatitis B virus infection
| Autor: | Fuchuan Wang, Aiqin Li, Jinfang Zhao, Yi Dong, Yanwei Zhong, Jiaye Liu, Jing Li, Jianguo Yan, Fu-Sheng Wang, Pu Wang, Shishu Zhu, Min Zhang, Lili Cao, Zhiqiang Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Biopsy Young children Gastroenterology Chronic hepatitis B Virus 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Fibrosis Internal medicine medicine Humans LSM 030212 general & internal medicine Prospective Studies Prospective cohort study Child Hepatology Receiver operating characteristic medicine.diagnostic_test business.industry Infant Newborn Infant Liver biopsy medicine.disease Liver ROC Curve Child Preschool Elasticity Imaging Techniques 030211 gastroenterology & hepatology Original Article Female Transient elastography business |
| Zdroj: | Hepatology International |
| ISSN: | 1936-0541 1936-0533 |
| Popis: | Background This study aimed to compare the diagnostic accuracy of transient elastography (TE) and biopsy for the detection of liver fibrosis in children with chronic hepatitis B (CHB). Methods This single-center prospective study included 157 CHB children aged 0–6 years. All patients underwent liver stiffness measurement (LSM) by TE and liver biopsy, separated by an interval of less than 1 week. Results The LSM, aspartate aminotransferase-platelet ratio index (APRI), and fibrosis-4 index (FIB-4) were positively correlated with activity grade and fibrosis stage in CHB children. The areas under the receiver operating characteristic curves (AUCs) of LSM for identifying significant (F ≥ 2) and advanced (F ≥ 3) fibrosis were 0.732 and 0.941, respectively. The cut-off values, specificity, and sensitivity for significant fibrosis were 5.6 kPa, 75.7%, and 67.4%, respectively; the corresponding values for advanced fibrosis were 6.9 kPa, 91.5%, and 81.3%, respectively. Compared to LSM, the overall diagnostic performances of APRI and FIB-4 for significant and advanced fibrosis were suboptimal, with low AUCs and sensitivity. Since LSM, platelet, and Log10 (hepatitis B surface antigen) were independent factors associated with the fibrosis stage (F p Conclusions TE is a promising technology for the diagnosis of advanced fibrosis in CHB children aged 0–6 years. |
| Databáze: | OpenAIRE |
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