Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

Autor: Johanna M. Gostner, Burkhard Schuetz, Dietmar Fuchs, Friedrich Leblhuber, Kostja Steiner
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Faecalibacterium prausnitzii
Gut flora
Systemic inflammation
Gastroenterology
law.invention
neuroinflammation
chemistry.chemical_compound
Probiotic
Feces
0302 clinical medicine
law
Medicine
Aged
80 and over
biology
Neopterin
Zonulin
Middle Aged
Neurology
Female
medicine.symptom
Alzheimer’s disease
medicine.medical_specialty
brain-gut axis
Cholera Toxin
Gut microbiota
Article
03 medical and health sciences
Alzheimer Disease
Internal medicine
Humans
Protein Precursors
Aged
Haptoglobins
business.industry
Probiotics
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
030104 developmental biology
chemistry
neopterin
Dietary Supplements
Neurology (clinical)
business
Mental Status Schedule
Dysbiosis
030217 neurology & neurosurgery
Kynurenine
dementia
Zdroj: Current Alzheimer Research
ISSN: 1875-5828
1567-2050
Popis: Background: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer’s disease. Objective: The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation. Methods: In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 ± 9.6 years) with Alzheimer’s disease were investigated. The mean Mini Mental State Examination score was 18.5 ± 7.7. Biomarkers of immune activation – serum neopterin and tryptophan breakdown - as well as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18 patients before and after probiotic supplementation for 4 weeks. Results: After treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium prausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations increased (p Conclusion: Results show that the supplementation of Alzheimer’s disease patients with a multispecies probiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation between Kyn/Trp and neopterin concentrations points to the activation of macrophages and/or dendritic cells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation in the course of Alzheimer’s disease.
Databáze: OpenAIRE
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