Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers

Autor:	Zuzana Kroneková, Peter Siffalovic, Dusan Chorvat, Leonid Satrapinskyy, Monika Majerčíková, Helena Valentová, Juraj Kronek, Peter Nádaždy, Anna Zahoranová
Rok vydání:	2021
Předmět:	Materials science stimuli-responsive polymers Polymers and Plastics crystallization ring-opening polymerization Organic chemistry 02 engineering and technology 010402 general chemistry 01 natural sciences Ring-opening polymerization Article symbols.namesake drug delivery systems QD241-441 Copolymer Thermoresponsive polymers in chromatography chemistry.chemical_classification Polarized light microscopy General Chemistry Polymer self-assembly 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering symbols Self-assembly 0210 nano-technology Drug carrier Raman spectroscopy
Zdroj:	Polymers Volume 13 Issue 9 Polymers, Vol 13, Iss 1357, p 1357 (2021)
ISSN:	2073-4360
Popis:	Thermoresponsive polymers play an important role in designing drug delivery systems for biomedical applications. In this contribution, the effect of encapsulated hydrophobic drug dexamethasone on thermoresponsive behavior of diblock copolymers was studied. A small series of diblock copoly(2-oxazoline)s was prepared by combining thermoresponsive 2-n-propyl-2-oxazoline (nPrOx) and hydrophilic 2-methyl-2-oxazoline (MeOx) in two ratios and two polymer chain lengths. The addition of dexamethasone affected the thermoresponsive behavior of one of the copolymers, nPrOx20-MeOx180, in the aqueous medium by shifting the cloud point temperature to lower values. In addition, the formation of microparticles containing dexamethasone was observed during the heating of the samples. The morphology and number of microparticles were affected by the structure and concentration of copolymer, the drug concentration, and the temperature. The crystalline nature of formed microparticles was confirmed by polarized light microscopy, confocal Raman microscopy, and wide-angle X-ray scattering. The results demonstrate the importance of studying drug/polymer interactions for the future development of thermoresponsive drug carriers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04825fe79993fab4b6c091e9443b6796 https://pubmed.ncbi.nlm.nih.gov/33919321 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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