Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS
Autor: | Georgia Xiromerisiou, Fani Zacharaki, Maria Gkaraveli, Georgios Hadjigeorgiou, Alexandros Papadimitriou, Vana Tsimourtou, Paraskevi Rodopoulou, Efthimios Dardiotis, Konstantinos Aggelakis, Styliani Ralli, Dimitris Bourpoulas |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Neurology TaqI medicine.drug_class Interleukin-1beta Dermatology Severity of Illness Index White People Cohort Studies chemistry.chemical_compound Sex Factors Polymorphism (computer science) Genotype medicine Humans Genetic Predisposition to Disease Age of Onset Polymorphism Genetic Greece business.industry Multiple sclerosis Interleukin General Medicine Receptor antagonist medicine.disease Interleukin 1 Receptor Antagonist Protein Psychiatry and Mental health Variable number tandem repeat Phenotype chemistry Case-Control Studies Immunology Disease Progression Female Neurology (clinical) business |
Zdroj: | Neurological Sciences. 31:253-257 |
ISSN: | 1590-3478 1590-1874 |
DOI: | 10.1007/s10072-009-0155-2 |
Popis: | We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI -511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility to and the clinical characteristics in Greek multiple sclerosis (MS) patients cohort with bout-onset. Genotypes were determined from 351 patients with clinically definite MS and 375 age- and sex-matched healthy controls. Our results showed no significant differences in the distribution of these polymorphisms between MS patients and controls. Furthermore, stratification for clinical characteristics, such as age at disease onset, clinical course, sex, and severity did not provide significant differences between patients and controls. Together, our findings suggest that IL-1B and IL-1RN gene polymorphisms may not be relevant to the susceptibility to MS or the clinical characteristics of Greek MS patients. |
Databáze: | OpenAIRE |
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