Distinct clinical characteristics and helminth co-infections in adult tuberculosis patients from urban compared to rural Tanzania

Autor: Grace Mhalu, Lukas Fenner, Mohamed Sasamalo, Francis Mhimbira, Jürg Utzinger, Stefanie Knopp, Marcel Tanner, Jerry Hella, Christoph Hatz, Liliana K. Rutaihwa, George Sikalengo, Klaus Reither, Khadija Said, Maja Weisser, Farida Bani, Sebastien Gagneux, Lujeko Kamwela, Yeromin P. Mlacha, Robert Ndege, Emilio Letang
Rok vydání: 2018
Předmět:
Adult
Male
Rural Population
medicine.medical_specialty
Tuberculosis
Adolescent
Urban Population
030231 tropical medicine
Helminthiasis
610 Medicine & health
Tanzania
lcsh:Infectious and parasitic diseases
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
360 Social problems & social services
Interquartile range
Internal medicine
parasitic diseases
Epidemiology
medicine
Humans
Schistosomiasis
lcsh:RC109-216
030212 general & internal medicine
Helminth infection
Coinfection
business.industry
lcsh:Public aspects of medicine
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
General Medicine
Odds ratio
Middle Aged
medicine.disease
Co-infection
Infectious Diseases
Female
Median body
Recurrent tuberculosis
Rural area
business
Body mass index
Research Article
Cohort study
Zdroj: Infectious Diseases of Poverty
Sikalengo, George; Hella, Jerry; Mhimbira, Francis; Rutaihwa, Liliana K; Bani, Farida; Ndege, Robert; Sasamalo, Mohamed; Kamwela, Lujeko; Said, Khadija; Mhalu, Grace; Mlacha, Yeromin; Hatz, Christoph; Knopp, Stefanie; Gagneux, Sébastien; Reither, Klaus; Utzinger, Jürg; Tanner, Marcel; Letang, Emilio; Weisser, Maja and Fenner, Lukas (2018). Distinct clinical characteristics and helminth co-infections in adult tuberculosis patients from urban compared to rural Tanzania. Infectious diseases of poverty, 7(1), p. 24. BioMed Central 10.1186/s40249-018-0404-9
Infectious Diseases of Poverty, Vol 7, Iss 1, Pp 1-12 (2018)
ISSN: 2049-9957
Popis: Background Differences in rural and urban settings could account for distinct characteristics in the epidemiology of tuberculosis (TB). We comparatively studied epidemiological features of TB and helminth co-infections in adult patients from rural and urban settings of Tanzania. Methods Adult patients (≥ 18 years) with microbiologically confirmed pulmonary TB were consecutively enrolled into two cohorts in Dar es Salaam, with ~ 4.4 million inhabitants (urban), and Ifakara in the sparsely populated Kilombero District with ~ 400 000 inhabitants (rural). Clinical data were obtained at recruitment. Stool and urine samples were subjected to diagnose helminthiases using Kato-Katz, Baermann, urine filtration, and circulating cathodic antigen tests. Differences between groups were assessed by χ2, Fisher’s exact, and Wilcoxon rank sum tests. Logistic regression models were used to determine associations. Results Between August 2015 and February 2017, 668 patients were enrolled, 460 (68.9%) at the urban and 208 (31.1%) at the rural site. Median patient age was 35 years (interquartile range [IQR]: 27–41.5 years), and 454 (68%) were males. Patients from the rural setting were older (median age 37 years vs. 34 years, P = 0.003), had a lower median body mass index (17.5 kg/m2 vs. 18.5 kg/m2, P
Databáze: OpenAIRE
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