Differences in Trabecular Plate and Rod Structure in Premenopausal Women Across the Weight Spectrum
| Autor: | Kamryn T. Eddy, Madhusmita Misra, Allison Kimball, Katherine N. Bachmann, Alexander T. Faje, Erinne Meenaghan, Anne Klibanski, Melanie Schorr, Karen K. Miller, Pouneh K. Fazeli, Seda Ebrahimi, Suzanne Gleysteen, Diane Mickley, Vibha Singhal |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Anorexia Nervosa Endocrinology Diabetes and Metabolism Finite Element Analysis Clinical Biochemistry Context (language use) Muscle mass Biochemistry Body Mass Index High weight Weight-Bearing Fractures Bone Young Adult Bone volume fraction Absorptiometry Photon Endocrinology Internal medicine medicine Humans Computer Simulation Obesity Insulin-Like Growth Factor I Vitamin D Muscle Skeletal Amenorrhea Clinical Research Articles Tibia Femur Neck business.industry Biochemistry (medical) Middle Aged Healthy Volunteers Spine Radius Trabecular bone Premenopause Case-Control Studies Cancellous Bone Body Composition Lean body mass Female medicine.symptom Tomography X-Ray Computed business Body mass index |
| Zdroj: | J Clin Endocrinol Metab |
| ISSN: | 1945-7197 0021-972X |
| Popis: | ContextPremenopausal women with anorexia nervosa (AN) and obesity (OB) have elevated fracture risk. More plate-like and axially aligned trabecular bone, assessed by individual trabeculae segmentation (ITS), is associated with higher estimated bone strength. Trabecular plate and rod structure has not been reported across the weight spectrum.ObjectiveTo investigate trabecular plate and rod structure in premenopausal women.DesignCross-sectional study.SettingClinical research center.ParticipantsA total of 105 women age 21 to 46 years: (i) women with AN (n = 46), (ii) eumenorrheic lean healthy controls (HCs) (n = 29), and (iii) eumenorrheic women with OB (n = 30).MeasuresTrabecular microarchitecture by ITS.ResultsMean age (±SD) was similar (28.9 ± 6.3 years) and body mass index differed (16.7 ± 1.8 vs 22.6 ± 1.4 vs 35.1 ± 3.3 kg/m2; P < 0.0001) across groups. Bone was less plate-like and axially aligned in AN (P ≤ 0.01) and did not differ between OB and HC. After controlling for weight, plate and axial bone volume fraction and plate number density were lower in OB vs HC; some were lower in OB than AN (P < 0.05). The relationship between weight and plate variables was quadratic (R = 0.39 to 0.70; P ≤ 0.0006) (i.e., positive associations were attenuated at high weight). Appendicular lean mass and IGF-1 levels were positively associated with plate variables (R = 0.27 to 0.67; P < 0.05). Amenorrhea was associated with lower radial plate variables than eumenorrhea in AN (P < 0.05).ConclusionsIn women with AN, trabecular bone is less plate-like. In women with OB, trabecular plates do not adapt to high weight. This is relevant because trabecular plates are associated with greater estimated bone strength. Higher muscle mass and IGF-1 levels may mitigate some of the adverse effects of low weight or excess adiposity on bone. |
| Databáze: | OpenAIRE |
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