General Treatment of pH-Solubility Profiles of Weak Acids and Bases and the Effects of Different Acids on the Solubility of a Weak Base

Autor:	Paul E. Helms, Hetty G.H. Tan, Swee K. Hsi, William H. Streng
Rok vydání:	1984
Předmět:	chemistry.chemical_classification Chemical Phenomena Base (chemistry) Chemistry fungi Inorganic chemistry Pharmaceutical Science Salt (chemistry) Alkalies Hydrogen-Ion Concentration PH profile Solubility Acid–base reaction Weak base Acids
Zdroj:	Journal of Pharmaceutical Sciences. 73:1679-1684
ISSN:	0022-3549
DOI:	10.1002/jps.2600731203
Popis:	The pH–solubility profile of a weak acid or base is shown to be a function of its pKsp, and pKa, and uncharged species solubility. Equations are presented that can be used to calculate the solubility as a function of pH. These equations can also be used when there is added salt present. Experimental data was obtained in three cosolvent systems consisting of methanol–water and ethanol–water. Also, the effect of different acids on the solubility of a weak base is reported. A pronounced effect on the solubility by the addition of salt is explained in terms of the Ksp.
Databáze:	OpenAIRE
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