The Economic Burden of Abuse of Prescription Opioids: A Systematic Literature Review from 2012 to 2017
Autor: | Marcia Reinhart, Nina Shak, Lauren M. Scarpati, Cody Patton, Jennifer G. Erensen, Noam Y. Kirson |
---|---|
Rok vydání: | 2018 |
Předmět: |
Economics and Econometrics
medicine.medical_specialty Substance-Related Disorders Poison control Health administration 03 medical and health sciences Indirect costs 0302 clinical medicine Cost of Illness medicine Humans 030212 general & internal medicine Medical prescription Intensive care medicine health care economics and organizations Health economics business.industry Health Policy Opioid use disorder Health Care Costs General Medicine Opioid-Related Disorders medicine.disease Systematic review Absenteeism Systematic Review business 030217 neurology & neurosurgery |
Zdroj: | Applied Health Economics and Health Policy |
ISSN: | 1179-1896 1175-5652 |
Popis: | Background Abuse of prescription opioids [opioid use disorder (OUD), poisoning, and fatal and non-fatal overdose] is a public health and economic challenge that is associated with considerable morbidity and mortality in the USA and globally. Objective To systematically review and summarize the health economics literature published over the last 5 years that describes the economic burden of abuse of prescription opioids. Methods Findings from searches of databases including MEDLINE, Embase, and Cochrane CENTRAL as well as hand searches of multiple conference abstracts were screened against predefined inclusion criteria to identify studies reporting cost and healthcare resource utilization (HRU) data associated with abuse of prescription opioids. Results A total of 49 unique studies were identified. Most of the studies examined direct costs and HRU, which were substantially higher for abusers of prescription opioids than non-abuser controls in several matched cohort analyses (US$20,343–US$28,718 vs US$9716–US$14,079 for mean direct combined annual healthcare costs reported in 6 studies). Although only a small number of studies reported indirect costs, these findings suggest a high societal burden related to productivity losses, absenteeism, morbidity, and mortality among those who abuse opioids. Studies of medication-assisted treatment demonstrated that factors such as adherence, dose, formulation (film or tablet), and relapse during treatment, were associated with direct costs and HRU among treated patients. Conclusions This systematic literature review shows that abuse of prescription opioids is characterized by substantial direct healthcare costs, medical utilization, and related societal costs. Future research should further investigate the indirect costs of opioid abuse. Electronic supplementary material The online version of this article (10.1007/s40258-018-0402-x) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
Externí odkaz: |