Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
| Autor: | Sandra Carvalho, Cátia Cilene dos Santos Naziazeno, Vinícius Souza dos Santos, Iraci Lucena da Silva Torres, Andressa de Souza, Júlia Schirmer Saldanha, Wolnei Caumo, Prisla Ücker Calvetti, Felipe Fregni, António Jorge da Costa Leite, Rael Lopes Alves, Maxciel Zortea |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2018 |
| Předmět: |
Male
Working memory training medicine.medical_specialty Fibromyalgia Science medicine.medical_treatment Prefrontal Cortex Neuropsychological Tests Audiology Transcranial Direct Current Stimulation Ensaio clínico controlado aleatório Article Executive Function 03 medical and health sciences Cognition 0302 clinical medicine medicine Memory span Humans Learning Verbal fluency test Cognitive Dysfunction Episodic memory 030203 arthritis & rheumatology Science & Technology Multidisciplinary Transcranial direct-current stimulation Working memory business.industry Middle Aged Fibromialgia Executive functions 3. Good health Dorsolateral prefrontal cortex Memory Short-Term Biomarcadores medicine.anatomical_structure Medicine Female business 030217 neurology & neurosurgery |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports Repositório Institucional do Centro Universitário La Salle Universidade La Salle (UNILASALLE) instacron:UNILASALLE |
| ISSN: | 2045-2322 |
| Popis: | Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM. financiamento: This research was supported by grants and material support from the following Brazilian agencies: Committee for the Development of Higher Education Personnel - CAPES - PNPD/CAPES and material support. National Council for Scientific and Technological Development - CNPq (grants to Dr. I.L.S. Torres, Dr. W. Caumo). Postgraduate Program in Medical Sciences at the School of Medicine of the Federal University of Rio Grande do Sul (material support). Postgraduate Research Group at the Hospital de Clinicas de Porto Alegre - FIPE HCPA (material support). Foundations for Support of Research at Rio Grande do Sul (FAPERGS) (material support). |
| Databáze: | OpenAIRE |
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